The grade matrix
Every supplement EBL grades, one row each, with a letter for every use it was tested for. The same substance can hold a B for one use and a D for another, because a grade belongs to the use, not the bottle. Each name opens the record and its trials.
109 supplements, 196 graded uses. Sorted by the best letter each one holds. The scale and what each letter requires: how grades work →
- AMuscle strength with resistance training in older adults
- CMemory and cognition in older adults
- CMajor depressive disorder, as an adjunct A treatment tested on top of standard prescribed therapy rather than in place of it. to SSRI treatment
- DBone mineral density in postmenopausal women
- BLipid profile (LDL Low-density lipoprotein cholesterol, the cholesterol fraction most closely tied to plaque in the arteries., triglycerides)
- CGlycemic control (fasting glucose, HbA1c A blood test that reflects average blood sugar over the previous two to three months.)
- CSystemic inflammation (CRP) and endothelial function
- BStress and cortisol
- BGlucose and LDL cholesterol
- BHigh-intensity exercise capacity
- BOsteoarthritis pain
- BFasting glucose
- BChronic heart failure events, including hospitalization, as an adjunct to standard therapy
- CStatin-associated muscle symptoms
- BActivity-related joint pain in athletes and active adults
- CSkin hydration, elasticity and wrinkles in adults
- BLDL cholesterol
- BGlycemic markers
- BFirst-stroke prevention in hypertensive adults without prior stroke or MI, in populations without grain folate fortification (0.8 mg/day with enalapril)
- DMajor cardiovascular events in people with vascular disease (folic acid with vitamins B6 and B12)
- BCognitive symptoms in mild to moderate dementia
- CMild cognitive impairment
- DDementia prevention in older adults
- BSkin hydration, elasticity and wrinkle depth in adults
- CKnee symptoms in adults with knee osteoarthritis or knee discomfort
- BPCOS metabolic measures
- BSleep onset timing in delayed sleep phase disorder
- BJet lag symptoms after flights across five or more time zones
- CSleep onset latency and sleep quality (primary sleep disorders)
- CPrevention of delirium in older hospitalized/medical-ward patients
- CPrevention of delirium after cardiac surgery
- DPrevention of delirium in the general intensive care unit
- BResting blood pressure
- BSecondary prevention after myocardial infarction
- BMajor adverse cardiovascular events, high-dose icosapent ethyl
- CDNA methylation clocks of biological aging in adults 70 and older
- DPrimary prevention in general-risk adults (mixed EPA+DHA)
- BDepression scales
- BFracture prevention, vitamin D3 with calcium, older adults living in institutions
- CFall prevention (older adults)
- CPrevention of acute respiratory tract infection (esp. in vitamin D-deficient people)
- CProgression from prediabetes to type 2 diabetes
- DDeficiency correction & fracture risk (deficient or older adults)
- DCancer prevention (already-replete adults)
- DCardiovascular prevention (already-replete adults)
- DFracture prevention (already-replete adults)
- DAll-cause mortality (older adults not selected for vitamin D status)
- DPrevention of depression in adults aged 50 and over
- BCommon-cold duration in adults
- CCommon-cold duration in children
- CSlowing progression to advanced age-related macular degeneration in people at high risk (zinc 80 mg with copper)
- CDepressive symptoms
- DFatigue in quiescent inflammatory bowel disease
- CCognition in MCI
- CWeight regain after diet-induced weight loss, adults with overweight or obesity
- DInsulin sensitivity and metabolic markers in overweight or insulin-resistant adults
- CDiabetic neuropathy symptoms
- CCognitive scores in MCI
- CSkin moisture and elasticity
- CWrinkle depth
- CSkin protection from ultraviolet light
- CBlood markers of oxidative stress
- CCholesterol, blood pressure and arterial stiffness
- CMuscle damage markers after exercise
- CScreen-related eye strain in children
- CBlood pressure
- CDiabetic neuropathy measures
- CGlycemic markers
- CKnee pain
- CIntestinal permeability
- CGlycemic markers in prediabetes or type 2 diabetes
- DMusculoskeletal measures (strength, lean mass, bone) in prediabetes or type 2 diabetes
- COffspring developmental measures
- COsteoarthritis pain and function, chondroitin as generally sold
- CKnee osteoarthritis pain and function, with glucosamine
- CGlycemic markers
- CMemory, chronic cerebral disorders
- CExercise performance
- CSystemic inflammatory markers (hs-CRP High-sensitivity C-reactive protein, a blood marker of low-grade inflammation., IL-6)
- CKnee osteoarthritis pain and function
- CHormone metabolism
- CVerbal learning in MCI
- CBlood glucose after a meal or glucose drink
- CCardiac output and filling pressures in heart failure
- DExercise capacity in heart failure with preserved ejection fraction
- DEndurance exercise performance
- DMigraine prevention
- DBlood pressure
- CGlycated serum protein
- CSleep, mood and heart-rate variability
- CKnee osteoarthritis
- CGlutathione status
- CFatigue after sleep restriction
- CGlutathione, oxidative stress and aging markers in older adults (originating group's trial)
- DGlutathione redox status in healthy older adults
- CGlycemic markers
- CEndothelial markers
- CMuscle mass and handgrip strength in adults with diagnosed sarcopenia Age-related loss of muscle mass and strength.
- CMuscle mass and strength in adults over 50 without sarcopenia
- DStrength and hypertrophy in resistance-trained young men
- CBlood pressure in adults
- DAerobic and endurance exercise performance, free L-citrulline
- CWorking memory during acute stress
- CRespiratory and systemic symptom scores in healthy adults
- DPrevention of respiratory infection in adults
- CMild cognitive impairment
- CCognitive decline in MCI
- CSleep quality in primary insomnia (older adults)
- DCardiovascular events and all-cause mortality
- CMemory retrieval and contextual memory after a single oral dose of about 260 mg
- DDaily low-dose methylene blue for memory or cognition
- CLiver enzymes
- CBrachial artery flow-mediated dilation in older adults
- DPhysical function in healthy older adults
- DEndurance exercise performance and training adaptation
- CSleep quality and duration
- CRecovery of muscle strength after strenuous exercise
- CSymptoms in schizophrenia, as an adjunct to antipsychotic treatment
- CCOPD exacerbation rate at 600 mg twice daily in moderate to severe COPD
- COvulation and pregnancy in clomiphene-resistant polycystic ovary syndrome, NAC added to clomiphene
- CMuscle insulin sensitivity in prediabetic postmenopausal women
- CBlood NAD+ Nicotinamide adenine dinucleotide, a molecule cells use in energy metabolism. Its level falls with age in some tissues. concentration in healthy middle-aged adults
- DLongevity, healthspan or mortality
- CSix-minute walk distance in peripheral artery disease
- CBlood NAD+ concentration in healthy and clinical adults
- DInsulin sensitivity in obese insulin-resistant men
- DCognition in mild cognitive impairment
- DEarly Parkinson disease
- CWalking distance in claudication
- CErectile function in mild to moderate erectile dysfunction, Korean red ginseng
- CLDL cholesterol
- CMemory and cognition in older adults, bovine-cortex phosphatidylserine (no longer sold)
- DMemory and cognition in older adults, soy-derived phosphatidylserine (the form sold)
- CCognitive performance in older adults
- CPrevention of antibiotic-associated C. difficile diarrhea (at-risk hospitalized patients)
- CInflammatory markers in type 2 diabetes
- CUpper respiratory infections in healthy adults (Lacticaseibacillus rhamnosus CRL 1505 only)
- CBlood pressure in adults with raised cholesterol
- DLDL cholesterol in adults enrolled for raised cholesterol
- CBlood pressure at 500 mg/day or more
- DBlood lipids
- DGlycemic control in metabolic syndrome and related disorders
- DSenolytic A compound intended to clear senescent cells: older cells that have stopped dividing but remain in tissue. use for aging outcomes, quercetin alone
- CSecondary prevention after myocardial infarction
- CImmune cell measures as an adjunct to cancer treatment
- DBlood glucose, lipids and blood pressure in type 2 diabetes and metabolic syndrome
- CMetabolic markers in obese men
- DExercise training adaptations in older men (resveratrol added to training)
- CFatigue
- CMajor depressive disorder, SAM-e as monotherapy
- DMajor depressive disorder, SAM-e added to an antidepressant
- DKnee or hip osteoarthritis, pain and function
- CAutoimmune thyroiditis (TPO antibodies)
- DLong-term supplementation in already-replete adults
- CSwelling after oral or sinus surgery
- DSystemic inflammation, cardiovascular or longevity use
- CGlucose control in diabetes
- CAcute exercise performance (3km running time)
- CGlycemic control in type 2 diabetes
- CEndothelial and inflammatory markers in type 2 diabetes
- DAging, longevity, mortality
- CHomocysteine An amino acid in the blood that rises when vitamin B12, folate or B6 are low.
- CTotal testosterone in men with low testosterone
- CSurvival added to chemotherapy
- CMuscle endurance and strength
- CArterial stiffness
- CUpper respiratory infections
- DAtrial fibrillation recurrence after catheter ablation
- DNo human randomized trial of standalone apigenin has been run. Route 1 No human randomized trial has been run, so the record rests on animal or mechanistic evidence only. One of the two routes to the lowest letter on EBL's scale.: cell, animal and...
- DNo randomized trial has tested rhamnan sulfate on plaque or vascular outcomes; one small...
- DTested at scale for cancer prevention in six large trials. Beta-carotene alone raised...
- DBone density and steroid hormone markers. The small controlled trials that exist were...
- DTendon, ligament and gut tissue healing. No result of a human randomized controlled trial People are assigned to the treatment or a comparison by chance, so the groups differ only in what they received. It is the design that can show cause and effect....
- DBromelain alone has been tested in placebo-controlled trials for knee osteoarthritis pain...
- DNo human trial of oral C60 has been run; the only human randomized trials of fullerene...
- DNo randomized trial of Ca-AKG on an aging outcome has reported. A placebo-controlled...
- DNo randomized trial of fisetin as a senolytic for aging has reported results. Small...
- DNo human randomized trial of the statin-muscle claim has reported, and no registered...
- DOlfactory recovery after COVID-19, luteolin alone
- DSymptom severity in Gulf War illness, luteolin alone
- DNo randomized trial has tested oral NAD+ itself on a clinical, functional or...
- DTested at scale on top of statins. Extended-release niacin alone (AIM-HIGH) and...
- DPSA kinetics in non-metastatic biochemically relapsed prostate cancer
- DCollagen turnover and cardiac remodeling markers in hypertension with raised galectin-3
- DKnee osteoarthritis symptoms
- DNo human trial has been run, and no human dose or safety data exist. Route 1: preclinical...
- DNo human trial has been published. Route 1: mouse and cell work only. The founding mouse...
- DGrowth hormone and IGF-1 response in older adults
- DBody composition and lean mass in older adults
- DCognition in older adults
- DMortality, frailty and longevity
- DAging, longevity, mortality
- DMemory in older adults with subjective cognitive decline
- DProposed autophagy The process cells use to break down and recycle their own worn-out parts. inducer, untested for that claim in people. The one oral trial in...
- DNo randomized trial has been run. Route 1: one open-label Everyone in the trial knows which treatment they are receiving, so expectations can shape the results, especially for symptoms people report themselves., uncontrolled trial of the...
- DMajor cardiovascular events