Affiliate & medical disclaimer.

Specifically, you should not:

• Use any content on this site as a substitute for professional medical advice, diagnosis, or treatment.
• Start, stop, or adjust any medication, supplement, or health protocol based solely on information presented here without first consulting a physician or other qualified healthcare provider.
• Disregard professional medical advice or delay seeking it because of something you have read on this site.
• Assume that any supplement graded highly on this site is safe or appropriate for your individual health situation. Individual responses to supplements vary and depend on factors only your healthcare provider can assess.

The author is not acting in any clinical or prescriptive capacity in producing this content. No content on this site creates a physician–patient relationship or any other form of professional–client relationship.

If you are pregnant, nursing, taking prescription medications, or have a pre-existing medical condition, consult your healthcare provider before using any supplement described on this site. Many supplements have meaningful interactions with medications and contraindications A condition or medication that makes a treatment unsafe or unsuitable for a particular person. in certain health conditions, the Contraindications Search and Medication Audit are designed to help surface them before you talk to your clinician.

In the event of a medical emergency, call your local emergency number (e.g., 911 in the United States) immediately.

EBL applies a proprietary evidence-tier rating system (Grades A–D) to longevity supplements, compounds, devices, and interventions. These ratings represent our independent assessment of the quality, consistency, and relevance of the published scientific literature, nothing more and nothing less.

Our evidence ratings are not:

• Evaluations by the U.S. Food and Drug Administration (FDA). The FDA does not evaluate or approve dietary supplements for safety or efficacy before they are marketed.
• Clinical recommendations, treatment guidelines, or endorsements from any medical or scientific body.
• Guarantees of safety, efficacy, or health outcomes for any individual.
• Statements that a supplement will prevent, treat, cure, or mitigate any disease or health condition.

How tiers are assigned. The editor reviews peer-reviewed research (randomized controlled trials People are assigned to the treatment or a comparison by chance, so the groups differ only in what they received. It is the design that can show cause and effect., systematic reviews A review that searches for every study on a question using a method set in advance, then assesses them together., meta-analyses A study that pools the numbers from several trials into one combined estimate., and observational Research that watches what people already do rather than assigning a treatment. It can show that two things travel together, not that one causes the other. studies) and applies a structured rubric: study size, methodology quality, replication The same finding reproduced by a separate research group. A result seen once can be chance or bias; a replicated one is harder to explain away. across independent labs, relevance to human longevity endpoints The outcome a trial measures to decide whether the treatment worked, such as heart attacks, blood pressure or a symptom score., and recency of findings. Animal-only data never enters a grade. The full methodology is described on the Learn / Methodology page.

Scientific understanding of longevity and supplementation is evolving rapidly. A rating assigned today may not reflect findings published in the future. We endeavor to update ratings as significant new evidence emerges; every revision is logged publicly on What's New.

A high evidence tier indicates that a body of published research supports a hypothesis, not that the compound has been proven to extend human lifespan or improve health outcomes in every individual.

The value of EBL depends entirely on readers trusting that ratings and content are not for sale. The following principles govern editorial process:

• Affiliate relationships do not determine coverage. We review based on research significance and editorial judgment. It is worth being concrete rather than pious about this: EBL holds a commercial link with a single ungraded device product, and no supplement, protocol, medication or device modality on this site carries an affiliate relationship of any kind. There is no supplement affiliate program here that could influence a review, because there is no supplement affiliate program here at all.
• No payment for ratings. No company or individual may pay to improve a supplement's evidence tier, featured status, or ranking. Any such request will be declined and publicly noted if persistent.
• Grades are independent of commerce. We earn no commission on any supplement, and no product carries a grade. Where a paid device sits under a graded therapy, the product says so beside its buy link, and the letter cannot be bought or moved by a commercial relationship. A higher commission never lifts a product up the tier ladder, a Grade A stays Grade A and a Grade C stays Grade C on the evidence alone. The complete list of what EBL earns anything on is six ungraded relationships, and it is in Section 01.
• No sponsored reviews without clear disclosure. If we ever publish sponsored content (content for which compensation was received) it will be prominently labeled "Sponsored" or "Paid Partnership" and segregated from independently produced reviews. As of the effective date above, EBL does not accept sponsored reviews.
• Criticism is not suppressed by commercial relationships. If we identify meaningful risks, limitations, or evidence gaps in a product sold by any partner, we report them, and the interaction and contraindication data on this site is written to surface them rather than to sell around them. Our obligation is to readers, not to commercial relationships.
• Conflicts disclosed proactively. Where the editor or any reviewer holds a personal, financial, or professional relationship with a brand being reviewed, that reviewer is excluded from the editorial process for that review. The full conflict of interest policy appears on the Learn page.

This editorial-independence statement is made voluntarily and reflects EBL's operating standards. Readers who identify content they believe has been influenced by commercial factors are encouraged to contact us.

References to specific brands, products, organizations, researchers, or publications on this site do not imply that those parties endorse EBL, our methodology, or our ratings. All product names, trademarks, and registered marks are the property of their respective owners.

Citations to published research are provided for transparency and ease of verification. The authors or institutions whose work we cite have not reviewed or approved our interpretation of their findings. We make every effort to represent research accurately; readers are encouraged to review the primary sources cited (PubMed links are provided throughout the site).

To the fullest extent permitted by applicable law, EBL and its operator disclaim all liability for any direct, indirect, incidental, special, consequential, or punitive damages arising from:

• Your use of or reliance on any content, product, service, or recommendation on this site;
• Any health outcome, adverse event, or interaction resulting from supplement use described on this site;
• Inaccuracies or errors in evidence summaries or ratings;
• Your use of any third-party website linked from this site;
• Any interruption, suspension, or termination of the site or its content.

This site and all its content are provided on an "as is" and "as available" basis without warranties of any kind, express or implied, including but not limited to warranties of merchantability, fitness for a particular purpose, or non-infringement.

Some jurisdictions do not allow the exclusion of certain warranties or the limitation of liability for certain types of damages. In such jurisdictions, our liability will be limited to the fullest extent permitted by law.

Evidence Based Longevity is an independent educational platform. We do not sell, fulfill, ship, or handle any products directly. All purchases made through links on this site are transactions between you and the respective manufacturer, retailer, or dispensary.

This applies to all products linked from the site, supplements (Fullscript or brand direct), devices (manufacturer or authorized resellers), and diagnostic tests (TruDiagnostic, InsideTracker, Function Health, Everlywell, Marek Health, GRAIL, OmegaQuant, Berkeley Life, Elysium Health, etc.), which are the same vendors named in Section 01.

For supplements ordered through the Fullscript dispensary (linked from EBL via /go/buy), contact Fullscript directly at fullscript.com/contact for all order and return inquiries. Fullscript manages all fulfillment and customer service for dispensary orders.

Manufacturers, distributors and event organizers sometimes offer products or travel at no charge. This section sets out what EBL accepts, what it refuses, and what it publishes when it accepts anything.

What counts as a review unit. Any supplement, device, diagnostic, laboratory test, service or subscription of a type EBL grades or could grade, provided at no charge or reduced charge by a manufacturer, distributor, retailer or any party acting for one. This covers items received by any route: direct shipment, conference and exhibition-hall distribution, trade-show sampling, and items provided in connection with a meeting or interview.

Branded promotional goods, printed materials, meals and refreshments are outside EBL's evaluative scope, are not review units, and are not logged.

Receipt creates no obligation. EBL does not agree to evaluate, grade, list, mention or review any product in exchange for a review unit. A unit may be received and the product may never appear here. Receipt does not accelerate review, does not affect the order in which products are evaluated, and does not affect any grade assigned.

What EBL does not sell. EBL does not sell grades, placement, favorable characterization, review priority, or advance sight of unpublished content. No consideration of any kind creates an obligation regarding what EBL publishes.

Personal time is a separate matter and is not covered by this section. Where EBL's editor is compensated for his own time in the form of a product, meeting or fee, the product is logged in the register below and the arrangement conveys nothing about EBL's evaluative output.

Event attendance and hosted travel. EBL may accept travel, lodging, registration or hospitality from a conference or event organizer in connection with coverage of that event, subject to all of the following:

• Coverage is descriptive. It reports what was presented and by whom. It does not characterize any product as effective or promising.
• No advance review. The organizer receives no draft, no approval right, no right to request changes, and no assurance that anything will be published at all.
• No grade linkage. No product encountered at a hosted event is graded, regraded or listed as a consequence of the visit. Products enter the normal evaluation pipeline on published human trial evidence only.
• Disclosure appears at the top of any resulting coverage, naming the organizer and stating what was provided.
• The arrangement is listed in the register below.
• Hosted travel is accepted only from event organizers, never from a manufacturer directly. Where an organizer's event revenue comes substantially from exhibitors within EBL's graded scope, that is stated in the disclosure.

Where EBL attends an event at its own expense, nothing published about that event is owed to any party and no disclosure under this section applies.

What is never accepted:

• Cash payment for evaluation, review, coverage or placement.
• Consulting, advisory or speaking fees from any manufacturer whose products fall within EBL's graded scope.
• Equity or options in any such manufacturer.
• Any arrangement conditioned on the content of what EBL publishes.

Disclosure on entries. Any entry for a product where EBL received a review unit carries the notice "Evaluation unit provided by manufacturer" together with the date of receipt. The notice is permanent. It remains regardless of the grade assigned, regardless of any later commercial relationship, and regardless of whether the unit was returned or disposed of. It applies to Emerging Research entries as well as to graded ones.

Interaction with commissions. Where an entry carries both a review-unit disclosure and a commission relationship, both appear on the entry; neither replaces the other. EBL does not accept a review unit from a manufacturer with which a commission arrangement is under negotiation.

Retention. Review units are retained for reference or disposed of. They are not sold or resold.

This policy applies to every party without exception. It is published so that a reader can check EBL's conduct against a written rule rather than take an assurance on trust.

Questions about these disclosures, concerns about specific content, or requests related to affiliate relationships may be directed through the contact form.

EBL reserves the right to update these disclosures at any time. The effective date at the top of this page indicates when the most recent version was published. Material changes will be reflected in an updated effective date and logged on What's New. Continued use of the site following any update constitutes acceptance of the revised disclosures.

For privacy-related rights requests (CCPA / GDPR / UK GDPR), see the Privacy Policy.