Longevity science, by category.
Deep dives into every major longevity category, ranked by the quality of human trial evidence, not marketing spend. Start with a category, then take the specifics to the Evidence Engine.
Six supplements where randomized human trials reported net harm. Two risk signals from large observational datasets. Three deprescribing conversations documented in the literature that patients raise with their physicians. The longevity field is relentlessly additive; this is the other side of the ledger. EBL reports what the trials found and makes no recommendation either way.
Nutrient Gaps in America
Every prevalence figure shown with the exact cutoff, the body that set it, the survey and the cycle it came from. Four different things get called deficiency and only one of them can carry a grade. Starting with vitamin D, B12 and magnesium.
Registry Trace
How much of the evidence under each letter is independently traceable: indexed study design and public trial registration, counted across every graded citation on the site.
Mendelian Randomization
How genetic evidence tests whether a marker causes disease or only predicts it. The markers where the two answers differ, and why none of it moves a letter grade.
Emerging Research
Longevity research sorted by what has actually been tested in people. What is tracked without a human trial, and what already carries a grade.
Evidence Against
Human trials and large observational studies identifying interventions where risk may outweigh benefit. 6 RCT-proven harms, 2 risk signals, 3 deprescribing conversations. The other side of the ledger, and often where the biggest gains come from subtraction rather than addition.
Not medical advice. Evidence grade refers to published human research on an ingredient, not proof that any specific product produces a given result. Starting any supplement is a decision for your physician, especially alongside prescription medications. See EBL's Position on how we grade.