Heart Health & Longevity
Three things matter: ApoB Apolipoprotein B, a protein carried once on each cholesterol particle that can enter the artery wall, so it counts those particles directly., blood pressure, VO₂max The most oxygen the body can use during all-out exercise, a standard measure of aerobic fitness..
The letters on this page
Eleven interventions on this page. Every one carries a letter.
- •Statins lower circulating CoQ10. Whether that reflects a tissue deficit that matters clinically is unsettled, and the 2026 ACC/AHA dyslipidemia guideline advises against routine CoQ10 for statin-attributed muscle symptoms.
- •Beta-blockers can blunt heart-rate response and reduce measured exercise capacity. Training for performance on a beta-blocker is a question for a cardiologist.
- •Nattokinase measurably shifts clotting markers in humans, and Arterosil and Vascanox are expected to add to antiplatelet or anticoagulant effects. Combining any of them with anticoagulants or antiplatelets raises bleeding risk and belongs under physician oversight.
- •Omega-3 fatty acids can modestly affect platelet function; large cardiovascular trials generally have not shown a major increase in serious bleeding. High-dose regimens can increase atrial fibrillation risk.
PREDIMED: -30% MACE Major adverse cardiovascular events: heart attack, stroke and cardiovascular death counted together as one trial outcome.
VO₂max is among the strongest measured predictors of cardiovascular and all-cause mortality
Anything in this page is educational only. Whether to start, stop or change a supplement for this condition, and how it fits with any medication you take, is a decision for your clinician. The Drug-Nutrient Depletion tool and the Contraindications Search are designed to help you prepare that conversation.
These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.