Hypertension
Eight measurements, not one, the home-BP rule.
The letters on this page
Ten interventions on this page. Five carry a letter; five are listed without one, with the reason.
- •Licorice containing glycyrrhizin can raise blood pressure and lower potassium through a mineralocorticoid effect. That effect matters most in hypertension. DGL (deglycyrrhizinated licorice) has the glycyrrhizin removed.
- •Loop and thiazide diuretics are associated with lower magnesium and potassium. Associations with zinc and B vitamins are less consistent; the Drug-Nutrient Depletion tool lists that evidence.
- •Potassium supplements and potassium-based salt substitutes can raise blood potassium to dangerous levels in people taking ACE inhibitors, ARBs or potassium-sparing diuretics.
Meta-analysis A study that pools the numbers from several trials into one combined estimate.: -5.5/-3.0 mmHg
Dose-response across trials
Not graded for this use. Magnesium is graded for cardiovascular events and all-cause mortality, not for blood pressure as an endpoint in its own right.
Not graded for this use. Not separately graded. EBL grades interventions at a studied dose and protocol; habitual dietary intake does not have one.
Meta-analysis: -7.6 mmHg systolic
Not graded for this use. Not separately graded. Hibiscus has no authored record yet, so the meta-analysis figure shown has not been assessed against EBL's grading rules.
No randomized trial of the product has been run.
Not graded for this use. Omega-3's graded uses are cardiovascular event endpoints, not blood pressure.
Not graded for this use. CoQ10 is graded for chronic heart failure and statin-associated muscle symptoms. Blood pressure is not a graded use.
Two pooled analyses of small trials disagree on blood pressure (PMIDs 30788274, 30284051).
Anything in this page is educational only. Whether to start, stop or change a supplement for this condition, and how it fits with any medication you take, is a decision for your clinician. The Drug-Nutrient Depletion tool and the Contraindications Search are designed to help you prepare that conversation.
These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.