Fatty Liver (MASLD / NAFLD)
Fructose out. Fibroscan in.
The letters on this page
Eight interventions on this page. Three carry a letter; five are listed without one, with the reason.
- •Statins are not contraindicated in MASLD. Stopping a statin is a decision for a physician.
- •High-dose vitamin E can increase bleeding tendency, particularly with anticoagulants or antiplatelets, and pooled trial data have reported a higher risk of hemorrhagic stroke.
- •Berberine inhibits CYP3A4 and P-glycoprotein, so it can raise blood levels of drugs cleared that way, including cyclosporine. The full medication list is the starting point for that conversation with your physician.
Strongest single dietary lever
Not graded for this use. EBL has no graded record for fructose elimination as an intervention in its own right. The dietary pattern trials that exist test whole diets, not this component alone.
Not graded for this use. Omega-3's graded uses are cardiovascular event endpoints. Liver fat is not among them.
Lower fibrosis progression
Not graded for this use. Not separately graded. EBL grades interventions at a studied dose and protocol; habitual dietary intake does not have one.
PIVENS trial
Not graded for this use. EBL's vitamin E record grades cancer prevention and major cardiovascular events. Vitamin E in fatty liver disease is a different question with different trials, and it carries no letter here.
Liver enzymes fall a few units at very low certainty (Cochrane 2025, PMID 40552569); the two biopsy trials were null on their primary endpoints.
Not graded for this use. Curcumin's graded uses are systemic inflammatory markers and knee osteoarthritis pain and function. No cited trial on the curcumin record measures a hepatic endpoint.
Anything in this page is educational only. Whether to start, stop or change a supplement for this condition, and how it fits with any medication you take, is a decision for your clinician. The Drug-Nutrient Depletion tool and the Contraindications Search are designed to help you prepare that conversation.
These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.