High Triglycerides
Triglycerides travel in the same ApoB-carrying particles as LDL Low-density lipoprotein cholesterol, the cholesterol fraction most closely tied to plaque in the arteries., which is why non-HDL cholesterol and ApoB Apolipoprotein B, a protein carried once on each cholesterol particle that can enter the artery wall, so it counts those particles directly. are read alongside them.
The letters on this page
Five interventions on this page. Four carry a letter; one is listed without one, with the reason.
- •Omega-3 fatty acids can modestly affect platelet function; large cardiovascular trials generally have not shown a major increase in serious bleeding. High-dose regimens can increase atrial fibrillation risk.
- •Amla reduced platelet aggregation in human studies and prolonged bleeding time alongside aspirin or clopidogrel. That matters for anyone taking an anticoagulant, an antiplatelet or a BTK inhibitor such as ibrutinib, which impairs the same platelet response.
- •Berberine inhibits CYP3A4 and P-glycoprotein, so it can raise blood levels of drugs cleared that way, including cyclosporine. The full medication list is the starting point for that conversation with your physician.
- •Extended-release niacin lowers triglycerides and raises HDL, but in two large trials in patients already taking a statin, AIM-HIGH and HPS2-THRIVE, it did not reduce cardiovascular events, and HPS2-THRIVE recorded more serious adverse events, including myopathy and disturbed diabetes control.
Graded on cardiovascular events, not on the triglyceride number
Not graded for this use. Omega-3's graded uses are cardiovascular event endpoints, not triglycerides as an endpoint.
Anything in this page is educational only. Whether to start, stop or change a supplement for this condition, and how it fits with any medication you take, is a decision for your clinician. The Drug-Nutrient Depletion tool and the Contraindications Search are designed to help you prepare that conversation.
These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.