The Evidence-Based
Longevity Report.
The human-trial guide to supplements, devices, labs, and medication-nutrient risk. Every grade backed by published PubMed citations. No animal data. No paid placements.
The EBL Method
The order is the method. Medications are read first, because the literature associates prescription classes with nutrient depletions and that context changes what a later result means. The supplements already in the cabinet are read next, by the letter each one carries. Dietary patterns are the base the trials assume is in place before any supplement enters the conversation. Baseline markers are drawn before anything is added: there is no honest after without a before. The graded interventions are those carrying an A or B for the outcome in question, at the dose and form the trials actually studied. The same markers are read again on the interval the literature uses, because an intervention that never moved its own endpoint The outcome a trial measures to decide whether the treatment worked, such as heart attacks, blood pressure or a symptom score. has not made its case. What follows from any of it is decided by you and a licensed clinician, not by this site.
Supplements by Evidence Grade
Graded A-D by human RCT Randomized controlled trial: people are assigned to the treatment or a comparison by chance, so the groups differ only in what they received. It is the design that can show cause and effect. evidence. Grade A = replicated The same finding reproduced by a separate research group. A result seen once can be chance or bias; a replicated one is harder to explain away. RCTs on a hard clinical outcome, an objectively measured function, or a validated scale scored by a clinician blinded to treatment. Grade D = animal/in-vitro only or insufficient human data.
Top 10 Medication-Nutrient Depletions
The most clinically significant nutrient depletions caused by commonly prescribed medications.
The EBL Longevity Lab Panel
28 evidence-informed reference thresholds, each labeled by the kind of evidence behind it. 7 systems. Every threshold PMID-cited.
Full panel with EBL reference values, each classified, and PMIDs: evidencebasedlongevity.co/longevity-lab-panel.html
How to use this report
Step 1a: The Medication Reality Check at evidencebasedlongevity.co/engine/safety.html lists the nutrient depletions the literature associates with each medication entered, with the PMID attached. It does not comment on whether a medication should be taken, changed or stopped.
Step 1b: The Stack Audit at evidencebasedlongevity.co/stack-audit.html returns the letter each supplement already in the cabinet carries. Grade D means the human evidence is absent or negative; Grade C means it is thin or mixed.
Step 2: Nutrition Foundations at evidencebasedlongevity.co/nutrition.html sets out what the trials show about dietary patterns, the base the literature assumes is in place before any supplement enters the conversation.
Step 3: The EBL Longevity Lab Panel lists the markers the trials used as endpoints, with each threshold and its source. It prints for a clinician.
Step 4: The grades above show which interventions carry an A or B for a given outcome, at the dose and form the trials actually studied, and which carry nothing.
Step 5: The Smart Retest Guide at evidencebasedlongevity.co/retest-guide.html sets out which markers a given intervention targets and the interval the literature reads them on.
Step 6: The Physician Discussion Sheet at evidencebasedlongevity.co/engine/report.html collects the citations in one page. EBL grades evidence; the decision about your care is made by you and a licensed clinician.
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