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Evidence Based Longevity (EBL) Check what I take
Drug-Nutrient Depletion A fall in a nutrient's level caused by a medication, for example through reduced absorption or increased loss.

Alzheimer's / Dementia Medications

Common brand names: Donepezil (Aricept), Rivastigmine, Memantine

Evidence last reviewed July 2026

One nutrient listed against this medication. The most severe is marked moderate.

At a glance

At a glance

Alzheimer's / Dementia Medications
  • Phosphatidylserine + Omega-3 DHAModerate · Traditionally cited, limited evidence

Color shows how serious each listed effect is. The label beside it shows how strong the evidence is. The cards below explain each one and show its evidence.

Nutrients it can lower

Phosphatidylserine + Omega-3 DHA
ModerateTraditionally cited · limited evidence PMID 20523044

Mechanism, These medications manage symptoms but do not address the underlying phospholipid membrane deficiencies in neurons. Phosphatidylserine and DHA support the structural integrity of neuronal membranes.

Common signs, Progressive cognitive decline, neuronal membrane deterioration

Vakhapova et al. (Dement Geriatr Cogn Disord, 2010; PMID PubMed ID: the permanent number the US National Library of Medicine gives a published paper. Each one links to that paper's record on PubMed. 20523044): phosphatidylserine with omega-3 improved some memory measures in non-demented elderly with memory complaints. That is a supplement benefit, not a depletion caused by Alzheimer's drugs.

Common practice, not from a trial cited on this row

Phosphatidylserine was used at 100 mg three times daily with DHA-rich omega-3 at 2 g or more daily; this is discussed with the neurologist.

For your next appointment

A page for your next appointment

It prints or saves as a single page. Whether to add a supplement for a nutrient this medication may lower is a decision for your prescriber.

Disclosure

Medical disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.

Grades move when new trials publish. A free monthly email lists every grade EBL moved, with the reason and the trial behind it: the sign-up is on the Evidence Log →