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Evidence Based Longevity (EBL) Check what I take
Metabolic

Gut & Microbiome Health

The window before HbA1c A blood test that reflects average blood sugar over the previous two to three months. crosses 5.7%.

Evidence last reviewed May 2026

At a glance

The letters on this page

Three interventions on this page. Two carry a letter; one is listed without one, with the reason.

How it is measured

Endpoints The outcome a trial measures to decide whether the treatment worked, such as heart attacks, blood pressure or a symptom score. the trials measured
C. difficile prevention
No target value is set.
Intestinal permeability
No target value is set.
Metabolic/gut markers
No target value is set.

What has been graded

Interventions · evidence-graded
NG
Probiotics

Not graded for this use. Probiotics are graded C for preventing antibiotic-associated C. difficile diarrhea in at-risk hospitalized patients. General gut health is not a graded use.

C
Akkermansia muciniphila
C
Bovine Colostrum (permeability)

Cautions

Cautions
  • •Probiotic benefit is strain- and indication-specific; it does not generalize across products.
  • •Probiotic-associated bloodstream infection is rare but documented. Risk is higher in severe immunocompromise, critical illness, central venous catheters and short-bowel syndrome; probiotic use in these settings requires clinician oversight.
When to consult your physician

Anything in this page is educational only. Whether to start, stop or change a supplement for this condition, and how it fits with any medication you take, is a decision for your clinician. The Drug-Nutrient Depletion tool and the Contraindications Search are designed to help you prepare that conversation.

Disclosure

Medical disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.