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Evidence Based Longevity (EBL)Check what I take
Evidence Trace, complete trial record
In plain terms

In plain terms: Amla (Indian Gooseberry, Emblica officinalis) has some human trial evidence supporting it, but the evidence is not yet strong enough for EBL to call it established. It is worth knowing about and worth discussing with your clinician.

Amla (Indian Gooseberry, Emblica officinalis)

B Supported: a good trial, backed by more
Category Supplements
Evidence RCT + meta-analysis of randomized trials
Reviewed July 2026
PMIDs 36934568 · 31060549
The endpoint this grade is based on: Surrogate biomarker endpoint, Lipid profile improvement (LDL, triglycerides); modest glycemic and anti-inflammatory (CRP) support; endothelial function in metabolic syndrome

The evidence as the record states it

Evidence record
PMID 36934568 PMID 31060549

Setayesh et al. (Diabetes Metab Syndr, 2023; PMID 36934568): systematic review and meta-analysis of RCTs: Amla supplementation improved lipid profile, glucose, and C-reactive protein in adults. Usharani et al. (BMC Complement Altern Med, 2019; PMID 31060549): randomized double-blind placebo-controlled trial: standardized Phyllanthus emblica extract improved endothelial function, systemic inflammation, and lipid profile in metabolic syndrome. Grade B on lipids; glycemic and CRP effects are more modest (Grade C).

PMID 36934568 PMID 31060549

Evidence by specific use

Lipid profile (LDL, triglycerides)
Grade B
Setayesh 2023 meta-analysis of RCTs (PMID 36934568) and Usharani 2019 RCT (PMID 31060549) show consistent reductions in LDL and triglycerides. Surrogate endpoints; no hard-outcome data.
PMID 36934568 PMID 31060549
PMID 36934568 PMID 31060549
Glycemic control (fasting glucose, HbA1c)
Grade C
Setayesh 2023 meta (PMID 36934568) found modest glucose reduction; effect smaller and less consistent than the lipid effect.
PMID 36934568
PMID 36934568
Systemic inflammation (CRP) and endothelial function
Grade C
Reduced CRP and improved endothelial function in metabolic-syndrome RCTs; small trials, surrogate markers.
PMID 36934568 PMID 31060549
PMID 36934568 PMID 31060549

Why Grade B and not Grade A

Grade B reflects moderate human evidence -- typically a single strong trial, multiple smaller trials, or surrogate endpoint data without hard clinical outcome replication. To reach Grade A, Amla (Indian Gooseberry, Emblica officinalis) would require at least one additional independent randomized trial demonstrating a hard clinical endpoint or objectively measured functional outcome in a comparable population.

What this grade covers and what it does not

Grade B on lipids (meta-analysis of RCTs plus a double-blind RCT, consistent LDL/triglyceride reduction). Grade C on glycemic control and inflammation (smaller, less consistent effects). Surrogate endpoints throughout; no hard-outcome data.

What would move this grade

An independent randomized trial demonstrating a hard clinical endpoint -- mortality, major adverse event, or objectively confirmed functional improvement -- in an adequately powered sample, with results independently replicated, would support Grade A.

How to track whether this is working Lipid panel (LDL, triglycerides), fasting glucose/HbA1c, hs-CRP at 12 weeks