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Evidence Based Longevity (EBL) Check what I take
Medication

BTK Inhibitors (Ibrutinib / Imbruvica)

Common brand names: Imbruvica (ibrutinib), Calquence (acalabrutinib), Brukinsa (zanubrutinib), Jaypirca (pirtobrutinib)

Evidence last reviewed September 2026

No nutrient depletion A fall in a nutrient's level caused by a medication, for example through reduced absorption or increased loss. is listed against this medication.

At a glance

In plain words

BTK inhibitors, such as Imbruvica, are cancer medicines for some blood cancers. This site lists no nutrient they are known to lower. These medicines can raise the risk of bleeding, and this site notes supplements that also affect bleeding, such as nattokinase. It does not tell anyone to start, stop or change a medicine.

Nutrients it can lower

No nutrient depletion recorded

EBL lists no nutrient that this medication is shown to lower. The record exists so that what is listed below reaches anyone who enters this medication.

Supplements with a recorded interaction

Each row is printed in full, with its sources, on the supplement's own page. A recorded interaction is not a finding of harm; whether it matters for one person is a question for the prescriber.

Nattokinase

Nattokinase and ibrutinib: two bleeding routes, no combined study. Read the row →

Amla

Amla and ibrutinib: both reduce the platelet response to collagen. Read the row →

Omega-3 (high-dose EPA)

Omega-3 and ibrutinib: both associated with atrial fibrillation. Read the row →

Berberine HCl

Berberine inhibits CYP3A4, the enzyme that clears ibrutinib. Read the row →

Vitamin E (supplemental)

Vitamin E and ibrutinib: both bear on bleeding. Read the row →

For your next appointment

A page for your next appointment

It prints or saves as a single page. Whether to add a supplement for a nutrient this medication may lower is a decision for your prescriber.

Disclosure

Medical disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.

Grades move when new trials publish. A free monthly email lists every grade EBL moved, with the reason and the trial behind it: the sign-up is on the Evidence Log →

Build 4c30f94, October 2026