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Evidence Based Longevity (EBL) Check what I take
Medication

PDE-5 inhibitors

Common brand names: Viagra, Cialis, Levitra, Stendra

Evidence last reviewed September 2026

No nutrient depletion A fall in a nutrient's level caused by a medication, for example through reduced absorption or increased loss. is listed against this medication.

At a glance

In plain words

PDE-5 inhibitors, such as Viagra and Cialis, are medicines for erection problems. This site lists no nutrient they are known to lower. It notes supplements that also lower blood pressure, such as citrulline, which matter with these medicines. It does not tell anyone to start, stop or change a medicine.

Nutrients it can lower

No nutrient depletion recorded

EBL lists no nutrient that this medication is shown to lower. The record exists so that what is listed below reaches anyone who enters this medication.

Supplements with a recorded interaction

Each row is printed in full, with its sources, on the supplement's own page. A recorded interaction is not a finding of harm; whether it matters for one person is a question for the prescriber.

Vascanox HP

Mechanism-based, no human interaction study located. Read the row →

L-Citrulline

The blood-pressure half is pooled; the drug half is not. Read the row →

L-Citrulline

The word nitrate is doing two jobs, and the count knows only one. Read the row →

For your next appointment

A page for your next appointment

It prints or saves as a single page. Whether to add a supplement for a nutrient this medication may lower is a decision for your prescriber.

Disclosure

Medical disclaimer

These statements have not been evaluated by the Food and Drug Administration. Any grade on this page describes the strength of published human trial evidence in the populations studied. It is not a recommendation for any individual and is not medical advice. Starting, stopping or changing any supplement or medication is a decision for your physician.

Grades move when new trials publish. A free monthly email lists every grade EBL moved, with the reason and the trial behind it: the sign-up is on the Evidence Log →

Build 4c30f94, October 2026