12 Hallmarks · 24 Questions · Evidence-Ranked Interventions

Hallmarks of Aging Mapper

Answer 24 questions about your symptoms and patterns. This tool maps your responses to the 12 Hallmarks of Aging framework and returns evidence-ranked interventions for your highest-scoring hallmarks.

Hallmarks

Questions

2023

Cell Framework

The Science

The 12 Hallmarks of Aging Framework

In 2013, López-Otín and colleagues published a landmark framework identifying nine hallmarks of aging in Cell. The framework was updated and expanded to 12 hallmarks in 2023 (López-Otín et al., Cell, 2023), adding Disabled Macroautophagy, Chronic Inflammation, and Dysbiosis as new pillars. Today this is the dominant scientific framework for understanding the molecular and cellular drivers of biological aging. Each hallmark represents a distinct but interconnected mechanism — understanding which are most active in your biology is the first step toward targeted intervention.

Genomic Instability

DNA damage accumulation

Telomere Attrition

Chromosome end shortening

Epigenetic Alterations

Methylation pattern drift

Loss of Proteostasis

Protein quality control failure

Disabled Macroautophagy

Cellular cleanup dysfunction

Deregulated Nutrient Sensing

mTOR/AMPK/sirtuins imbalance

Mitochondrial Dysfunction

Energy production decline

Cellular Senescence

Zombie cell accumulation

Stem Cell Exhaustion

Regenerative capacity decline

Altered Intercellular Communication

Inflammaging and SASP

Chronic Inflammation

Systemic low-grade inflammation

Dysbiosis

Gut microbiome disruption

Source: López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. “Hallmarks of aging: An expanding universe.” Cell. 2023;186(2):243–278. doi:10.1016/j.cell.2022.11.001

Self-Assessment

0 / 24 answered

Rate each question: Never (0), Rarely (1), Sometimes (2), Often (3). Questions marked with (R) are reverse-scored.

Genomic Instability

DNA damage accumulation

How often do you notice slow wound healing?

Never Rarely Sometimes Often

Do you have a family history of early cancer?

Never Rarely Sometimes Often

Telomere Attrition

Chromosome end shortening

How would you rate your perceived aging vs. peers your age? (Feeling older than your age)

Much younger About the same Somewhat older Much older

Have you experienced significant chronic psychological stress over many years?

Never Rarely Sometimes Often

Epigenetic Alterations

Methylation pattern drift

How consistent is your sleep schedule? (R)
Reverse scored — inconsistent sleep = higher risk

Very consistent Mostly consistent Irregular Very irregular

How would you rate your long-term diet quality? (R)
Reverse scored — poor diet = higher risk

Excellent Good Poor Very poor

Loss of Proteostasis

Protein quality control failure

Do you experience eye floaters, joint stiffness, or tissue cloudiness?

Never Rarely Sometimes Often

How often do you experience brain fog or mental slowness?

Never Rarely Sometimes Often

Disabled Macroautophagy

Cellular cleanup dysfunction

Do you practice any form of intermittent fasting or time-restricted eating? (R)
Reverse scored — fasting supports autophagy

Daily Often Rarely Never

Do you experience difficulty losing weight despite diet changes?

Never Rarely Sometimes Often

Deregulated Nutrient Sensing

mTOR/AMPK/sirtuins imbalance

How often do you experience energy crashes after meals?

Never Rarely Sometimes Often

Do you have elevated fasting glucose, insulin resistance, or metabolic syndrome markers?

Never Rarely Sometimes Often

Mitochondrial Dysfunction

Energy production decline

How would you rate your energy levels throughout the day? (R)
Reverse scored — low energy = higher dysfunction

Excellent Good Low Very low

Do you experience muscle fatigue disproportionate to your activity level?

Never Rarely Sometimes Often

Cellular Senescence

Zombie cell accumulation

Do you experience chronic low-grade pain or stiffness without clear injury?

Never Rarely Sometimes Often

Have you noticed slower recovery from illness or physical stress than in your 30s?

Never Rarely Sometimes Often

Stem Cell Exhaustion

Regenerative capacity decline

How is your physical recovery after exercise compared to 10 years ago?

Better About the same Somewhat worse Much worse

Have you noticed thinning hair, slower nail growth, or reduced skin repair?

Never Rarely Sometimes Often

Altered Intercellular Communication

Inflammaging and SASP

Do you have any diagnosed autoimmune conditions or elevated chronic inflammatory markers?

Never Rarely Sometimes Often

Do you experience unexplained fatigue, brain fog, or multi-system symptoms without clear diagnosis?

Never Rarely Sometimes Often

Chronic Inflammation

Systemic low-grade inflammation

Do you have elevated CRP, ESR, or other inflammation markers on blood tests?

Never Rarely Sometimes Often

How often do you experience joint pain, gum disease, or skin inflammation?

Never Rarely Sometimes Often

Dysbiosis

Gut microbiome disruption

How would you rate your digestive health (bloating, irregularity, food sensitivities)?

Excellent Occasional issues Frequent issues Persistent issues

Have you taken multiple courses of antibiotics in the past 5 years?

Never 1 course 2–3 courses 4+ courses

Your Results

Your Hallmarks Profile

Scores are based on your self-reported symptoms and patterns. Higher scores indicate greater alignment with that hallmark's known risk factors.

All 12 Hallmarks Overview

Top 3 Hallmarks — Evidence-Based Interventions

Evidence Protocol

See Your Full 12-Hallmark Protocol

Your free results show your top 3 hallmarks and 1 intervention each. The full Evidence Protocol includes your complete 12-hallmark ranked profile, 3–5 interventions per hallmark with dose and timing, supplement stacking guidance, and lab tests to confirm each driver.

Complete 12-hallmark ranking Full intervention protocol Dose + timing guidance Confirming lab tests Supplement stacking rules

Get My Evidence Protocol →

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