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Recently Answered
A growing archive of evidence-grounded answers. Names never published.
What's the single highest-impact supplement for someone over 50 with no known deficiencies?
Based on the breadth of human trial data, Magnesium Glycinate is the most broadly evidence-supported starting point. Roughly 45% of US adults are deficient (NHANES), and adequacy underpins 300+ enzymatic reactions including ATP synthesis, DNA repair, and cardiovascular function. Omega-3 (EPA+DHA) is a close second given the cardiovascular mortality data.
Is creatine safe for long-term use in older adults?
Yes — the evidence is reassuring. A 2021 meta-analysis in the Journal of the International Society of Sports Nutrition found no adverse effects on kidney function in healthy adults with long-term use at 3–5g/day. Creatine is one of the most studied supplements in existence with 500+ peer-reviewed trials.
Do I need to cycle NAD+ precursors or can I take them continuously?
The cycling question remains open in the literature. Current human trials (Yoshino 2021 in Science, Martens 2023 in Nature Aging) do not show evidence of tolerance or diminishing returns with continuous NMN/NR use. That said, some practitioners prefer an "on/off" approach out of caution — there's no human data supporting this as necessary.