Our Methodology

Why most longevity sites are indistinguishable from marketing

The longevity supplement market is worth $50 billion. The incentive to sell is enormous. The incentive to be honest about what the evidence actually shows — almost nonexistent. Evidence Based Longevity was built on a single premise: if you can't cite the trial, you can't make the claim.

Every product, device, and testing protocol on this site cleared a published human clinical trial threshold before it appears. Here is exactly how that works.

RCTs Only Randomized controlled trials drive ratings
Tier A–D Evidence-graded — not marketing-graded
Zero Paid placements. Ever.
Cochrane-aligned Same hierarchy used in systematic medicine
The Evaluation Process

How every product is assessed

No product reaches this site by sponsoring a conference, running ads, or paying a placement fee. Every product goes through the same five-step evaluation, in order. Failure at any step is a disqualifier.

01

PubMed Literature Review

We search PubMed for all human clinical trials on the active ingredient, filtered for randomized controlled trials (RCTs) and peer-reviewed meta-analyses. Animal data and in-vitro studies are noted but never used as the primary evidence basis for a recommendation.

Human trials only
02

Dose Matching

We compare the product's actual label dose against the effective dose range used in the published trials. Products that underdose — a common industry practice — are penalized in their evidence rating regardless of the ingredient's underlying merit. A real dose in a real trial, or it doesn't count.

Label dose vs. trial dose
03

Form & Bioavailability

Molecular form determines whether you absorb anything at all. Magnesium oxide vs. glycinate. Ubiquinone vs. ubiquinol. NMN vs. NR. Liposomal vs. standard. We evaluate which form was used in the trials that showed efficacy — and whether the product in front of us matches that form.

Bioavailability scored
04

Third-Party Verification

What's on the label must match what's in the bottle. We require COA availability from ISO-accredited labs for Tier A–B listings. Independent certification (NSF, USP, Informed Sport, IFOS) elevates a product's rating. Claims of purity without verification are treated as unverified.

NSF · USP · IFOS · COA
05

Conflict of Interest Audit

We check whether the trials supporting a product were funded by its manufacturer, conducted by researchers with financial ties to the brand, or published in pay-to-play journals. Industry-funded studies are weighted less heavily. Independent replication in separate research groups is required for a Tier A rating. Affiliate commission relationships are disclosed on every product page — but commissions are never a factor in tier assignment. The evidence gates are passed first, always.

Independent replication required for Tier A
Supplement Evidence Tiers

The four-tier evidence system

Every supplement in our database is assigned one of four evidence tiers based on the quality and volume of published human clinical research. Tier assignment reflects the evidence — not the popularity, price, or marketing spend of the product.

Tier A
5/5

Landmark Evidence

Multiple high-quality RCTs and systematic meta-analyses in humans. Effect sizes replicated across independent research groups. Decades of safety data. These are the compounds that have earned the scientific consensus — not because a brand paid for it, but because the evidence accumulated across decades of independent research and survived the scrutiny of systematic reviews.

Omega-3 fatty acids · Magnesium glycinate · Vitamin D3+K2 · CoQ10 Ubiquinol · Creatine monohydrate
Tier B
4/5

Strong Evidence

Multiple human RCTs with consistent results across independent groups. Mechanistic pathways well-established and biologically plausible. Some limitations in trial scale, duration, or population size. The evidence is compelling and actionable — these are serious compounds, not trend supplements. Gaps exist but are acknowledged explicitly.

NMN · NR (Niagen®) · Curcumin Phytosome · Berberine · Quercetin · Cocoa Flavanols · Ashwagandha KSM-66 · Fatty15
Tier C
3/5

Moderate / Emerging Evidence

Human trials exist but are limited in scale, number, or reproducibility. Promising preclinical and mechanistic data support biological plausibility. Listed with explicit evidence caveats — the compound is scientifically credible but the clinical evidence base is not yet sufficient to recommend without qualification. Worth watching as trials accumulate.

Spermidine Life · Fisetin · Taurine · Lion's Mane · Astaxanthin · EGCG · Rhodiola · HAELO (sPEMF)
Tier D
2/5

Early / Mechanism-Only

Preliminary human data or strong mechanistic rationale without robust clinical trials. The biology is real but the clinical proof is not yet there. Listed only when the safety profile is established and the mechanistic case is sufficiently strong. Always accompanied by explicit caveats and a disclosure of the evidence gap.

Epithalon · Melatonin (longevity dose) · Klotho pathway compounds · Emerging peptide protocols
Not Listed

Does Not Meet Evidence Threshold

Products built on pseudoscience, quantum energy claims, undisclosed mechanisms, or marketing narratives with no peer-reviewed human trial data are not listed — regardless of how popular they are, who endorses them, or how prominent their conference sponsorship. This is a non-negotiable filter.

Quantum energy subscriptions · "Tachyon-charged" amino acids · Unverifiable frequency devices · Products with no published human data

Why we use the Cochrane hierarchy

The Cochrane Review is the gold standard for medical evidence — an independent international non-profit that produces systematic reviews pooling data from hundreds of randomized controlled trials, filtering out industry-funded bias, small sample sizes, and statistical noise. When a treatment earns a favorable Cochrane conclusion, it has survived the most rigorous scrutiny in medicine. This site applies the same hierarchical framework: RCTs and meta-analyses drive ratings; anecdote, influencer endorsement, and marketing copy do not.

Device & Technology Tiers

How we evaluate devices differently

Devices present a different evaluation challenge than supplements. FDA clearance, clinical trial design, and mechanism complexity all factor differently. We apply a modified tier system that accounts for the regulatory and clinical realities of the device category.

A key distinction: individual modality evidence (e.g., photobiomodulation) vs. product-specific evidence (e.g., this specific device at this specific dose). We flag which type of evidence is driving the rating on every device card.

Tier A · 4–5/5

FDA-Cleared with RCT Support

FDA-cleared for the indicated use, supported by multiple independent RCTs, and modality-level evidence is substantial. Device operates at clinically validated parameters.

Tier B · 3–4/5

Strong Modality Evidence

Modality is well-supported in peer-reviewed literature. Product-specific RCTs may be limited but parameters match published clinical protocols. Mechanism is biologically established.

Tier C · 2–3/5

Emerging / Plausible

Mechanism is plausible and modality has some pilot data. Product-specific clinical evidence is limited or preliminary. Listed with explicit caveats and a clear statement of what is and is not yet proven.

Editorial Standards

What we don't do — and why

The longevity industry has a specific set of incentive problems that corrupt most sites in this space. We address each of them explicitly.

Paid placements

Brands do not pay to appear on this site. There is no sponsored content, no advertorial, no "featured partner" tier that gets you listed above competitors. The evidence threshold is the only entry criteria.

Commission-driven rankings

Affiliate commission relationships are disclosed on every product page. But a higher commission never moves a product up the tier ladder. The rankings reflect evidence strength, period.

Trend-chasing

If a compound goes viral on social media but lacks published human trial data, it does not appear here. Popularity is not evidence. Conference sponsorship is not evidence. Influencer adoption is not evidence.

Exaggerated claims

We never extrapolate from animal data to human outcomes without stating that explicitly. When a study is industry-funded, we say so. When the evidence is limited, we say so. The caveats are not buried in fine print.

Evidence evolves — so do our ratings

A product rated Tier C today may earn Tier B when a new independent RCT publishes. A product rated Tier A may be downgraded if a large meta-analysis contradicts earlier findings. Ratings are reviewed when new significant trials are published.

This is not medical advice

Evidence-based does not mean personalized. What a population-level RCT shows may not apply to your individual physiology, medications, or health conditions. Every recommendation on this site includes a "discuss with your physician" standard — especially for pharmaceutical-grade compounds, devices, and peptides.

Founder independence

The Founder of Evidence Based Longevity has no financial stake in any supplement manufacturer, device company, or testing laboratory featured on this site. Recommendations are made from a position of clinical experience and independent research review — not commercial interest.

47 years of clinical context

Ratings are informed by five decades of nutrition and clinical health practice — not just a literature search. That experience shapes which signals matter, which study designs are trustworthy, and which industry narratives deserve skepticism.

The Philosophy

Why this matters

The people who most need reliable longevity information are often the most at risk of being misled. High-net-worth individuals are targeted by premium-priced products with sophisticated marketing and no clinical backing. Busy professionals don't have time to read the primary literature. And most "evidence-based" wellness sites use that phrase as a marketing headline, not an actual standard.

The goal of this site is simple: create the resource that a serious, skeptical physician — with 47 years of clinical experience and no financial conflicts — would hand to a patient who asked "what actually works?"

Arnold Sandlow

Arnold Sandlow

Founding Professor of Anti-Aging Studies  ·  A4M Diplomate  ·  47 Years in Nutrition & Clinical Health

I spent nearly five decades in clinical practice watching patients spend thousands of dollars on supplements that had no real evidence behind them — and miss the ones that did. The longevity space has always attracted brilliant researchers and relentless marketers, often in the same room. I built Evidence Based Longevity because I wanted one place where the standard was simple and non-negotiable: if there is no peer-reviewed human trial, the claim does not get made. After 47 years of reading the literature, treating patients, and watching trends come and go, I have a pretty clear sense of what holds up. This site is my attempt to put that filter to work for people who are serious about their health but do not have the time or background to wade through the primary research themselves.

"The restraint is the brand signal. If we tell you something works, it works. If we tell you the evidence is limited, we mean it. That's the only promise this site makes — and it's the only one that matters."
— Arnold Sandlow · Founding Professor of Anti-Aging Studies · A4M Diplomate · 47 Years in Nutrition & Clinical Health

See the methodology in action

Browse the full research library — every product, device, and testing protocol rated and cited.