Submit a Compound for Review

Compound Submission Form

All fields marked Required must be completed. Submissions without at least 3 PubMed-linked human RCTs will not enter the review queue.

Compound / Product Name Required Use the ingredient name, not a brand name. Include the specific form if relevant (e.g. "Ashwagandha KSM-66").

Category Required

Proposed Evidence Tier Required Be honest. Overstating evidence tiers is the most common error. We'd rather receive a Tier C submission with good reasoning than an inflated Tier A claim.

Dose Used in Trials Required This must match the dose in the trials you cite — not what's commonly sold. If the trial used a different dose than what's commercially available, note both.

Form Used in Trials Required Standard vs. enhanced bioavailability, specific branded extract, etc. This is the most common point of failure — many supplements are marketed citing trials that used a different, more bioavailable form.

PubMed Links (Human RCTs Only) Required — Min. 3

Links must be to PubMed (pubmed.ncbi.nlm.nih.gov). Animal studies, in-vitro studies, or mechanistic papers will not count toward the 3-study minimum. Cochrane reviews and meta-analyses of human trials are accepted.

Industry Funding / COI Disclosure Required Be accurate. Industry-funded studies are not automatically disqualifying — we just apply higher scrutiny and require independent replication for Tier A status.

Safety / Drug Interaction Flags Optional but strongly encouraged

Your Reasoning Optional

Your Email Optional — for review updates only We'll notify you when your submission enters active review. We don't use this for marketing.

All submissions are reviewed manually. We aim to acknowledge receipt within 7 days and complete full reviews within 60 days. Accepted compounds are added to the public review queue below.

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Submission Received

Thank you for contributing to the evidence base. We've received your submission and will acknowledge it within 7 days. If you provided an email, we'll notify you when it enters active review.

Browse All Categories →

📋 Current Review Queue

8 in queue

IN REVIEW

Taurine (1–3g/day)

Aging, cardiovascular, mitochondria · 12 submissions

IN REVIEW

Spermidine (1–2mg/day)

Autophagy, cardiovascular · 9 submissions

PENDING

Glycine (3–5g/day)

Sleep, longevity, collagen synthesis · 7 submissions

PENDING

Lithium (low-dose, 1–5mg)

Neuroprotection, longevity · 6 submissions

QUEUED

Alpha-Ketoglutarate (AKG)

Epigenetic aging, TCA cycle · 5 submissions

QUEUED

Pregnenolone (10–30mg)

Neurosteroid, cognitive, hormonal · 4 submissions

QUEUED

Benfotiamine (300–600mg)

AGE inhibition, neuroprotection · 3 submissions

QUEUED

Hydrogen Water (1–2L/day)

Oxidative stress, inflammation · 3 submissions

🔬 What Happens After Submission

Manual triage (7 days)

We confirm the compound hasn't been reviewed, verify PubMed links are human RCTs, and check for duplicate submissions.

Queue entry

Accepted submissions enter the public queue. Others who want the same review can upvote to raise priority.

Full review (30–60 days)

Our 5-step process: PubMed review → dose matching → bioavailability scoring → third-party verification → COI audit.

Publication

Reviewed compounds are added to the relevant category page with full evidence card, or listed as Tier D with explanation if evidence doesn't qualify.

Compound Submission Form

Submission Received

📋 Current Review Queue

🔬 What Happens After Submission

✅ Acceptance Criteria

🚫 What We Won't Review