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Drug Nutrient Depletion Guide

Sulfonylureas: What It Depletes and How to Replenish

Sulfonylureas (Glipizide, Glimepiride, Glyburide) is associated with clinically documented depletion of 1 key nutrient. Below you'll find the mechanism, clinical evidence, and evidence-based replenishment protocols for each.

This page is educational content based on published clinical trials. All supplement recommendations should be discussed with your prescribing physician before implementation. Evidence ratings follow the same RCT-first methodology used across the full Evidence Based Longevity database.
1 Documented Depletions · RCT Evidence
1
CoQ10
Moderate Depletion Risk
How It Depletes

Sulfonylureas suppress ATP-sensitive potassium channels in pancreatic cells — a mechanism that intersects with CoQ10-dependent mitochondrial energy pathways.

Clinical Evidence

Kishi et al. (1976) — CoQ10 depletion with early sulfonylurea compounds documented

Symptoms of Deficiency

Fatigue, reduced exercise tolerance, cardiovascular risk

Evidence-Based Replenishment

CoQ10 100–200mg daily.

View on Fullscript: Jarrow QH-Absorb Ubiquinol 100mg

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

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