Bile acid sequestrants bind bile acids needed for fat-soluble vitamin absorption. All four fat-soluble vitamins — A, D, E, K — are significantly impaired.
West & Lloyd (1975) — documented fat-soluble vitamin malabsorption; standard prescribing caution
Vitamin D deficiency, bone loss, immune impairment, Vitamin K deficiency (clotting issues), Vitamin E antioxidant depletion
Take fat-soluble vitamins 1–2 hours before OR 4 hours after cholestyramine dose. Supplement D3 + K2, Vitamin E (mixed tocopherols), Vitamin A (as retinol, not beta-carotene).
View on Fullscript: Thorne Vitamin D/K2 LiquidDiscuss with your physician before adjusting supplementation. This is educational content, not medical advice.
Bile acid sequestrants impair fat absorption broadly — omega-3 fatty acids from dietary and supplement sources are affected.
Jenkins et al. (1999) — fat-soluble nutrient absorption impaired with bile acid sequestrant use
Reduced cardiovascular protection, inflammatory burden increase
Take omega-3 supplements 4+ hours away from cholestyramine dose.
View on Fullscript: Nordic Naturals Ultimate Omega 2XDiscuss with your physician before adjusting supplementation. This is educational content, not medical advice.
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