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Drug Nutrient Depletion Guide

Benzodiazepines (Anti-Anxiety): What It Depletes and How to Replenish

Benzodiazepines (Anti-Anxiety) (Xanax, Klonopin, Valium, Ativan) is associated with clinically documented depletion of 1 key nutrient. Below you'll find the mechanism, clinical evidence, and evidence-based replenishment protocols for each.

This page is educational content based on published clinical trials. All supplement recommendations should be discussed with your prescribing physician before implementation. Evidence ratings follow the same RCT-first methodology used across the full Evidence Based Longevity database.
1 Documented Depletions · RCT Evidence
1
Melatonin
Moderate Depletion Risk
How It Depletes

Benzodiazepines suppress pineal melatonin release and alter sleep architecture — suppressing deep sleep and REM stages even when inducing sleep.

Clinical Evidence

Montagnese et al. (2011) — benzo-induced melatonin suppression

Symptoms of Deficiency

Non-restorative sleep, morning grogginess, daytime fatigue, rebound insomnia

Evidence-Based Replenishment

Discuss gradual benzo taper with prescriber. Melatonin 0.5–1mg may help sleep quality (discuss timing with prescriber).

View on Fullscript: Life Extension Melatonin 300mcg

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

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