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Drug Nutrient Depletion Guide

Alzheimer's / Dementia Medications: What It Depletes and How to Replenish

Alzheimer's / Dementia Medications (Donepezil (Aricept), Rivastigmine, Memantine) is associated with clinically documented depletion of 1 key nutrient. Below you'll find the mechanism, clinical evidence, and evidence-based replenishment protocols for each.

This page is educational content based on published clinical trials. All supplement recommendations should be discussed with your prescribing physician before implementation. Evidence ratings follow the same RCT-first methodology used across the full Evidence Based Longevity database.
1 Documented Depletions · RCT Evidence
1
Phosphatidylserine + Omega-3 DHA
Moderate Depletion Risk
How It Depletes

These medications manage symptoms but do not address the underlying phospholipid membrane deficiencies in neurons. Phosphatidylserine and DHA support the structural integrity of neuronal membranes.

Clinical Evidence

Vakhapova et al. (2010) — PS + DHA omega-3 improved cognitive outcomes; MIDAS trial DHA data

Symptoms of Deficiency

Progressive cognitive decline, neuronal membrane deterioration

Evidence-Based Replenishment

Phosphatidylserine 100mg 3× daily + DHA-rich omega-3 2g+ daily. Discuss with neurologist.

View on Fullscript: Thorne Phosphatidylserine (PS)

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

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